Mpox Vaccination

Mpox Vaccine Quick Facts

  • Dosing: The JYNNEOS vaccine is a 2-dose series taken at least 28 days apart. The best protection against both clade I and clase II mpox is reached 2 weeks after the second dose. There is no recommendation for a booster dose (a third dose) at this time.
  • Missed Doses: If your second dose is delayed, receive it as soon as possible. You do not need to restart the series.
  • Post-Exposure: If exposed, getting vaccinated within 4 days can help prevent infection, and within 14 days can reduce symptom severity.
  • Access & Cost: The vaccine is covered by public and private insurance, and is available regardless of sexual orientation, gender identity, or immigration status.
  • Side Effects: Common side effects of the JYNNEOS vaccine include tiredness, headache and muscle pain. There may also be redness, swelling, soreness and itchiness where you received the injection.

Who Should Get Vaccinated? (Eligibility)

Vaccination is recommended for:

  1. Recent Exposure: Anyone with known or suspected exposure to mpox within the last 14 days should contact their healthcare provider as soon as possible.
  2. Sexual Networks: Gay, bisexual, or other men who have sex with men (MSM), as well as transgender, nonbinary, or gender-diverse individuals, who in the last 6 months have had (or expect to have):
    • A diagnosed sexually transmitted infection (STI).
    • More than one sexual partner, or anonymous sexual or intimate contact.
    • Sex at a commercial sex venue (e.g. bathhouse), private sex party, or in association with a large public event.
    • Transactional sex (exchanging sex for money, goods, or other items).
  3. Occupational Risk: Anyone working in settings with potential exposures (e.g. laboratory workers).
  4. Health Status: Anyone living with HIV or taking pre-exposure prophylaxis (PrEP).
  5. Partners: Anyone whose sexual partners meet any of the criteria listed above.
  6. Travelers: Anyone traveling to a country with an active clade I or II mpox outbreak who anticipates new sexual partners, transactional sex, or sex at commercial venues/large public events during travel. See the Centers for Disease Control and Prevention's global mpox situation summary here.
  7. Anyone who self-identifies as being at risk for mpox.

Note: If you have allergies to vaccine ingredients, chicken, or egg protein, consult a healthcare provider before vaccination.

Where to Get the Vaccine